Abstract Lon is a conserved AAA+ (ATPases associated with diverse cellular activities) proteolytic machine that plays a key regulatory role in cells under proteotoxic stress.Lon-mediated proteolysis can be stimulated by either the unfolded or specific protein substrates accumulated under stress conditions.However, the molecular basis for this subst

The present study concerns the experimental investigation of foamed concretes with 1600 kg/m3 density that incorporate biochar additions in the mix.A series of small notched beams are prepared to determine the fracture energy in CMOD (crack mouth opening displacement) mode and the mechanical properties in terms of flexural and compressive strength.

The Roman bridge near Canosa di Puglia (Southern Italy) currently has a very different morphology from the one planned by its builders in the second century Batteries AD as part of the program for the construction of the Via Traiana.Although the piers, the abutments and the foundation platea are still preserved from the Roman age, the changes made

Over the past few years, it has become increasingly apparent that signal transduction pathways are not merely linear cascades; CAMPHOR they are organized into complex signaling networks that require high levels of regulation to generate precise and unique cell responses.However, the underlying regulatory mechanisms by which signaling pathways cross